InnateDB Protein
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IDBP-383542.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RPL10
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Protein Name
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ribosomal protein L10
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Synonyms
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AUTSX5; DXS648; DXS648E; L10; NOV; QM;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000413436
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InnateDB Gene
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IDBG-91249 (RPL10)
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Protein Structure
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Function |
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Subcellular Localization |
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Disease Associations |
Autism, X-linked 5 (AUTSX5) [MIM:300847]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269PubMed:16940977, ECO:0000269PubMed:21567917}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
95
[view]
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Protein-Protein |
92
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001197
Ribosomal protein L10e
IPR016180
Ribosomal protein L10e/L16
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PFAM |
PF00252
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PRINTS |
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PIRSF |
PIRSF005590
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P27635
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PhosphoSite |
PhosphoSite-P27635
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TrEMBL |
X5D2T3
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UniProt Splice Variant |
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Entrez Gene |
6134
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UniGene |
Hs.739235
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RefSeq |
NP_006004
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HUGO |
HGNC:10298
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OMIM |
312173
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CCDS |
CCDS14746
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HPRD |
02421
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IMGT |
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EMBL |
AB007170
AF486812
AK223309
BC003358
BC026276
BC071918
BX936346
BX936347
CH471172
CR456797
CR542069
DQ369703
DQ369704
DQ369705
DQ369706
DQ369707
DQ369708
DQ369709
DQ369710
DQ369711
DQ369712
DQ369713
DQ369714
DQ369715
DQ369716
KJ534934
L44140
M64241
M73791
M81806
S35960
S64168
S64169
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GenPept |
AAA36021
AAA36378
AAA63253
AAA92646
AAB22173
AAB27665
AAH03358
AAH26276
AAH71918
AAL88713
ABC88559
ABC88560
ABC88561
ABC88562
ABC88563
ABC88564
ABC88565
ABC88566
ABC88567
ABC88568
ABC88569
ABC88570
ABC88571
ABC88572
AHW56574
BAA28595
BAD97029
CAG33078
CAG46866
CAI43214
CAI43230
CAM45852
CAM45853
EAW72737
EAW72739
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