InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAA15

Summary

InnateDB Protein

IDBP-38410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAA15

Protein Name

N(alpha)-acetyltransferase 15, NatA auxiliary subunit

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296543

InnateDB Gene

IDBG-38408 (NAA15)

Protein Structure

UniProt Annotation

Function

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. {ECO:0000269PubMed:11687548, ECO:0000269PubMed:12145306, ECO:0000269PubMed:15496142}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

Disease Associations

Tissue Specificity

Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy. {ECO:0000269PubMed:11687548, ECO:0000269PubMed:12087473, ECO:0000269PubMed:12140756}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0016407	acetyltransferase activity
GO:0043022	ribosome binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006474	N-terminal protein amino acid acetylation
GO:0030154	cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050821	protein stabilization