Homo sapiens Protein: NAA15 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-38410.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | NAA15 | ||||||||||||||||||||||
Protein Name | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000296543 | ||||||||||||||||||||||
InnateDB Gene | IDBG-38408 (NAA15) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. {ECO:0000269PubMed:11687548, ECO:0000269PubMed:12145306, ECO:0000269PubMed:15496142}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy. {ECO:0000269PubMed:11687548, ECO:0000269PubMed:12087473, ECO:0000269PubMed:12140756}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR013026
Tetratricopeptide repeat-containing domain IPR019734 Tetratricopeptide repeat IPR021183 N-terminal acetyltransferase A, auxiliary subunit |
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PFAM |
PF13174
PF13176 PF13181 PF12569 |
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PRINTS | |||||||||||||||||||||||
PIRSF |
PIRSF000422
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SMART |
SM00028
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9BXJ9 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9BXJ9 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 80155 | ||||||||||||||||||||||
UniGene | Hs.741801 | ||||||||||||||||||||||
RefSeq | NP_476516 | ||||||||||||||||||||||
HUGO | HGNC:30782 | ||||||||||||||||||||||
OMIM | 608000 | ||||||||||||||||||||||
CCDS | CCDS43270 | ||||||||||||||||||||||
HPRD | 10471 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC097376 AF327722 AJ314788 AK023402 AY039242 AY112670 BC039818 BC093928 BC104806 CH471056 | ||||||||||||||||||||||
GenPept | AAH39818 AAH93928 AAI04807 AAK15707 AAK68661 AAM48746 AAY40950 BAB14562 CAC43228 EAX05119 | ||||||||||||||||||||||