|
InnateDB Protein
|
IDBP-384253.5
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
SLC25A28
|
|
Protein Name
|
solute carrier family 25, member 28
|
|
Synonyms
|
|
|
Species
|
Homo sapiens
|
|
Ensembl Protein
|
ENSP00000399102
|
|
InnateDB Gene
|
IDBG-86043 (SLC25A28)
|
|
Protein Structure
|
|
| Function |
Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}.
|
| Subcellular Localization |
Mitochondrion inner membrane {ECO:0000269PubMed:11297739}; Multi-pass membrane protein {ECO:0000269PubMed:11297739}. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion.
|
| Disease Associations |
|
| Tissue Specificity |
Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart. {ECO:0000269PubMed:11297739}.
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
1
[view]
|
| Protein-Protein |
0
|
| Protein-DNA |
0
|
| Protein-RNA |
0
|
| DNA-DNA |
1
[view]
|
| RNA-RNA |
0
|
| DNA-RNA |
0
|
|
|
|
Molecular Function |
|
| Biological Process |
|
| Cellular Component |
|
| PDB ID |
|
| InterPro |
IPR018108
Mitochondrial substrate/solute carrier
IPR023395
Mitochondrial carrier domain
|
| PFAM |
PF00153
|
| PRINTS |
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
|
| PhosphoSite |
PhosphoSite-Q96A46
|
| TrEMBL |
X6RFA8
|
| UniProt Splice Variant |
|
| Entrez Gene |
81894
|
| UniGene |
Hs.619091
|
| RefSeq |
|
| HUGO |
HGNC:23472
|
| OMIM |
609767
|
| CCDS |
|
| HPRD |
|
| IMGT |
|
| EMBL |
AL353719
|
| GenPept |
|
|
|
|
Version 5.4