InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFRKB

Summary

InnateDB Protein

IDBP-384650.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFRKB

Protein Name

nuclear factor related to kappaB binding protein

Synonyms

INO80G;

Species

Homo sapiens

Ensembl Protein

ENSP00000400476

InnateDB Gene

IDBG-76076 (NFRKB)

Protein Structure

UniProt Annotation

Function

Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269PubMed:18922472}.Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269PubMed:18922472}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18922472}.

Disease Associations

Tissue Specificity

Expressed in thymus, brain, testes, spleen and liver. {ECO:0000269PubMed:1777480}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006954	inflammatory response