InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SETD7

Summary

InnateDB Protein

IDBP-38483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETD7

Protein Name

SET domain containing (lysine methyltransferase) 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000274031

InnateDB Gene

IDBG-38481 (SETD7)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269PubMed:12540855, ECO:0000269PubMed:12588998, ECO:0000269PubMed:15099517, ECO:0000269PubMed:15525938, ECO:0000269PubMed:16141209, ECO:0000269PubMed:17108971}.

Subcellular Localization

Nucleus. Chromosome {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in pancreatic islets.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0018026	peptidyl-lysine monomethylation
GO:0018027	peptidyl-lysine dimethylation
GO:0034968	histone lysine methylation