InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANGPT4

Summary

InnateDB Protein

IDBP-38725.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANGPT4

Protein Name

angiopoietin 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371347

InnateDB Gene

IDBG-38723 (ANGPT4)

Protein Structure

UniProt Annotation

Function

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. {ECO:0000269PubMed:15284220}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in the lung with much lower levels found in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0001525	angiogenesis
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007596	blood coagulation
GO:0010595	positive regulation of endothelial cell migration
GO:0016525	negative regulation of angiogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900	leukocyte migration
GO:0071456	cellular response to hypoxia