Version 5.4
Homo sapiens Protein: HNRNPA3
Summary
InnateDB Protein IDBP-387747.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPA3
Protein Name heterogeneous nuclear ribonucleoprotein A3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000408487
InnateDB Gene IDBG-75837 (HNRNPA3)
Protein Structure
UniProt Annotation
Function Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269PubMed:11886857}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Component of ribonucleosomes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 80 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0008380 RNA splicing
GO:0010467 gene expression
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0030529 ribonucleoprotein complex
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51991
PhosphoSite PhosphoSite-P51991
TrEMBL Q8NFG3
UniProt Splice Variant
Entrez Gene 220988
UniGene Hs.597770
RefSeq XP_005246438
HUGO HGNC:24941
OMIM 605372
CCDS
HPRD
IMGT
EMBL AC079305 AF517524 AK293125 AK316434 AY363225 BC112027 BC113470 CH471058
GenPept AAI12028 AAI13471 AAM51824 AAQ63629 AAY14709 BAG56677 BAH14805 EAX11063 EAX11065 EAX11066

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca