InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC22A1

Summary

InnateDB Protein

IDBP-388155.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A1

Protein Name

solute carrier family 22 (organic cation transporter), member 1

Synonyms

HOCT1; OCT1; oct1_cds;

Species

Homo sapiens

Ensembl Protein

ENSP00000409557

InnateDB Gene

IDBG-98656 (SLC22A1)

Protein Structure

UniProt Annotation

Function

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase. {ECO:0000269PubMed:11388889, ECO:0000269PubMed:11408531, ECO:0000269PubMed:15389554, ECO:0000269PubMed:16272756, ECO:0000269PubMed:16581093, ECO:0000269PubMed:9187257, ECO:0000269PubMed:9260930, ECO:0000269PubMed:9655880}.

Subcellular Localization

Basolateral cell membrane {ECO:0000269PubMed:16263091}; Multi-pass membrane protein {ECO:0000269PubMed:16263091}.

Disease Associations

Tissue Specificity

Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO:0000269PubMed:11388889, ECO:0000269PubMed:9187257, ECO:0000269PubMed:9260930}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006855	drug transmembrane transport
GO:0015695	organic cation transport
GO:0034220	ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15245

PhosphoSite