InnateDB Protein
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IDBP-388223.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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QKI
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Protein Name
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QKI, KH domain containing, RNA binding
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Synonyms
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Hqk; hqkI; QK; QK1; QK3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000408382
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InnateDB Gene
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IDBG-98868 (QKI)
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Protein Structure
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Function |
RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients. {ECO:0000269PubMed:16342280}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
67
[view]
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Protein-Protein |
67
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004087
K Homology domain
IPR004088
K Homology domain, type 1
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PFAM |
PF00013
PF13014
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PRINTS |
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PIRSF |
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SMART |
SM00322
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TIGRFAMs |
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Modification |
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SwissProt |
Q96PU8
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PhosphoSite |
PhosphoSite-Q96PU8
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TrEMBL |
F5H8C8
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UniProt Splice Variant |
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Entrez Gene |
9444
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UniGene |
Hs.708585
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RefSeq |
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HUGO |
HGNC:21100
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OMIM |
609590
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CCDS |
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HPRD |
06691
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IMGT |
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EMBL |
AB067798
AB067799
AB067800
AB067801
AB067808
AF142417
AF142418
AF142419
AF142420
AF142421
AF142422
AK027309
AL031781
AL356119
AY780788
BC012222
BC019917
DQ323998
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GenPept |
AAF63412
AAF63413
AAF63414
AAF63415
AAF63416
AAF63417
AAH12222
AAH19917
AAV98358
ABC88600
BAB55032
BAB69496
BAB69497
BAB69498
BAB69499
BAB69681
CAI21651
CAI21652
CAI21653
CAI23022
CAI23023
CAI23024
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