Version 5.4
Homo sapiens Protein: PARD3B
Summary
InnateDB Protein IDBP-388517.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARD3B
Protein Name par-3 partitioning defective 3 homolog B (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000407718
InnateDB Gene IDBG-79260 (PARD3B)
Protein Structure
UniProt Annotation
Function Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Subcellular Localization Endomembrane system. Cell junction. Cell junction, tight junction. Note=Partially localized along the cell- cell contact region. Colocalizes with TJP1 to epithelial tight junctions.
Disease Associations
Tissue Specificity Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007049 cell cycle
GO:0051301 cell division
Cellular Component
GO:0005923 tight junction
GO:0012505 endomembrane system
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR021922 Protein of unknown function DUF3534
PFAM PF12053
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TEW8
PhosphoSite PhosphoSite-Q8TEW8
TrEMBL Q53SN0
UniProt Splice Variant
Entrez Gene 117583
UniGene
RefSeq
HUGO HGNC:14446
OMIM
CCDS
HPRD 09795
IMGT
EMBL AB053321 AB073472 AB092439 AC007385 AC007465 AC007736 AC007746 AC008168 AC008171 AC009316 AC011750 AC016903 AC108468 AF428250 AF428251 AF466152 AK056157 AK057965
GenPept AAL30664 AAL30665 AAL79827 AAX93083 BAB69028 BAB71106 BAB71623 BAC54035 BAC54285

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca