Version 5.4
Homo sapiens Protein: XRCC5
Summary
InnateDB Protein IDBP-388819.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRCC5
Protein Name X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Synonyms KARP-1; KARP1; KU80; Ku86; KUB2; NFIV;
Species Homo sapiens
Ensembl Protein ENSP00000401318
InnateDB Gene IDBG-80616 (XRCC5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 241 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 241 [view]
Protein-Protein 234 [view]
Protein-DNA 6 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
Cellular Component
GO:0043564 Ku70:Ku80 complex
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR005161 Ku70/Ku80, N-terminal alpha/beta
PFAM PF00092
PF03731
PRINTS
PIRSF
SMART SM00327
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL C9JZ81
UniProt Splice Variant
Entrez Gene 7520
UniGene Hs.597412
RefSeq
HUGO HGNC:12833
OMIM 194364
CCDS
HPRD 08935
IMGT
EMBL AC010686 AC012513
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca