InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP37

Summary

InnateDB Protein

IDBP-388912.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP37

Protein Name

ubiquitin specific peptidase 37

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000400902

InnateDB Gene

IDBG-81020 (USP37)

Protein Structure

UniProt Annotation

Function

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). {ECO:0000269PubMed:21596315}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in brain and prostate. {ECO:0000269PubMed:14715245}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007067	mitotic nuclear division
GO:0016579	protein deubiquitination
GO:0035871	protein K11-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR003903 Ubiquitin interacting motif
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF02809

PRINTS

PIRSF

SMART

SM00726

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86T82