InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LMNA

Summary

InnateDB Protein

IDBP-389040.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMNA

Protein Name

lamin A/C

Synonyms

CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; PRO1;

Species

Homo sapiens

Ensembl Protein

ENSP00000395597

InnateDB Gene

IDBG-103380 (LMNA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 247 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	247 [view]
Protein-Protein	239 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007077	mitotic nuclear envelope disassembly
GO:0007084	mitotic nuclear envelope reassembly
GO:0007517	muscle organ development
GO:0030334	regulation of cell migration
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034504	protein localization to nucleus
GO:0044267	cellular protein metabolic process
GO:0071456	cellular response to hypoxia
GO:0090343	positive regulation of cell aging

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005638	lamin filament
GO:0005652	nuclear lamina
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0016607	nuclear speck
GO:0048471	perinuclear region of cytoplasm