InnateDB Protein
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IDBP-389321.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DEDD
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Protein Name
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death effector domain containing
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Synonyms
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CASP8IP1; DEDD1; DEFT; FLDED1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000414821
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InnateDB Gene
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IDBG-104188 (DEDD)
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Protein Structure
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Function |
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in testis. {ECO:0000269PubMed:9832420}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
32
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001875
Death effector domain
IPR011029
Death-like domain
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PFAM |
PF01335
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PRINTS |
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PIRSF |
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SMART |
SM00031
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TIGRFAMs |
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Modification |
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SwissProt |
O75618
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PhosphoSite |
PhosphoSite-O75618
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TrEMBL |
V9GY27
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UniProt Splice Variant |
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Entrez Gene |
9191
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UniGene |
Hs.727157
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RefSeq |
NP_001034801
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HUGO |
HGNC:2755
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OMIM |
606841
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CCDS |
CCDS1219
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HPRD |
06022
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IMGT |
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EMBL |
AF043733
AF064605
AF083236
AF100341
AJ010973
AL591806
BC013910
BC016724
CH471121
CR536556
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GenPept |
AAC17110
AAC33105
AAC80280
AAD16414
AAH13910
AAH16724
CAA09445
CAG38793
CAI15381
EAW52648
EAW52650
EAW52651
EAW52652
EAW52653
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