Version 5.4
Homo sapiens Protein: UBE2F
Summary
InnateDB Protein IDBP-389503.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2F
Protein Name ubiquitin-conjugating enzyme E2F (putative)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000399183
InnateDB Gene IDBG-84388 (UBE2F)
Protein Structure
UniProt Annotation
Function Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. {ECO:0000269PubMed:19250909}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed (at protein level). {ECO:0000269PubMed:19250909}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0019788 NEDD8 ligase activity
Biological Process
GO:0008152 metabolic process
GO:0045116 protein neddylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969M7
PhosphoSite PhosphoSite-Q969M7
TrEMBL C9JF62
UniProt Splice Variant
Entrez Gene 140739
UniGene Hs.625007
RefSeq NP_001265236
HUGO HGNC:12480
OMIM
CCDS CCDS63177
HPRD 14812
IMGT
EMBL AC016776 AF310723 AK290063 AK293334 AK294107 AK297502 AK303094 BC010549 CH471063
GenPept AAH10549 AAL26792 AAY24220 BAF82752 BAG56850 BAG57442 BAG59915 BAG64204 EAW71129 EAW71132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca