InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRC

Summary

InnateDB Protein

IDBP-389846.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRC

Protein Name

protein tyrosine phosphatase, receptor type, C

Synonyms

B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200;

Species

Homo sapiens

Ensembl Protein

ENSP00000411355

InnateDB Gene

IDBG-105609 (PTPRC)

Protein Structure

UniProt Annotation

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:12676959}; Single-pass type I membrane protein {ECO:0000269PubMed:12676959}. Membrane raft {ECO:0000269PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts.

Disease Associations

Severe combined immunodeficiency autosomal recessive T- cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. {ECO:0000269PubMed:11145714}. Note=The disease is caused by mutations affecting the gene represented in this entry.Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269PubMed:11101853}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002378	immunoglobulin biosynthetic process
GO:0002711	positive regulation of T cell mediated immunity
GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159	leukocyte cell-cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007411	axon guidance
GO:0010332	response to gamma radiation
GO:0016311	dephosphorylation
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0031953	negative regulation of protein autophosphorylation
GO:0034113	heterotypic cell-cell adhesion
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042098	T cell proliferation
GO:0042100	B cell proliferation
GO:0042102	positive regulation of T cell proliferation
GO:0043410	positive regulation of MAPK cascade
GO:0044770	cell cycle phase transition
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0045087	innate immune response (InnateDB)
GO:0045577	regulation of B cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0048539	bone marrow development
GO:0048864	stem cell development
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0050855	regulation of B cell receptor signaling pathway
GO:0050857	positive regulation of antigen receptor-mediated signaling pathway
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle
GO:2000473	positive regulation of hematopoietic stem cell migration
GO:2000648	positive regulation of stem cell proliferation
GO:2001236	regulation of extrinsic apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR016335 Leukocyte common antigen
IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108
PF12567
PF12453

PRINTS

PR00700

PIRSF

PIRSF002004

SMART

SM00194
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References