Version 5.4
Homo sapiens Protein: NIP7
Summary
InnateDB Protein IDBP-39117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NIP7
Protein Name nuclear import 7 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000254940
InnateDB Gene IDBG-39115 (NIP7)
Protein Structure
UniProt Annotation
Function Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. {ECO:0000269PubMed:22195017}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:22195017}.
Disease Associations
Tissue Specificity Expressed in hematopoietic stem/progenitor cells. {ECO:0000269PubMed:15522784}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0042255 ribosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR002478 PUA domain
IPR005155 Ribosome biogenesis factor NIP7-like
IPR015947 PUA-like domain
IPR016686 Ribosome biogenesis factor, NIP7
PFAM PF01472
PF03657
PRINTS
PIRSF PIRSF017190
SMART SM00359
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y221
PhosphoSite PhosphoSite-Q9Y221
TrEMBL
UniProt Splice Variant
Entrez Gene 51388
UniGene Hs.585728
RefSeq NP_057185
HUGO HGNC:24328
OMIM
CCDS CCDS10877
HPRD 16709
IMGT
EMBL AB062398 AB062479 AB112439 AF085360 AF132971 AF161528 AK315355 BC015941 CH471092
GenPept AAD27746 AAD40195 AAF29143 AAH15941 BAB93485 BAB93504 BAD05056 BAG37751 EAW83271

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca