InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCTD12

Summary

InnateDB Protein

IDBP-39145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCTD12

Protein Name

potassium channel tetramerisation domain containing 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366694

InnateDB Gene

IDBG-39143 (KCTD12)

Protein Structure

UniProt Annotation

Function

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung. {ECO:0000269PubMed:15357420}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0051260	protein homooligomerization

Cellular Component

GO:0030054	cell junction
GO:0042734	presynaptic membrane
GO:0043235	receptor complex
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome