Version 5.4
Homo sapiens Protein: ORMDL2
Summary
InnateDB Protein IDBP-39161.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORMDL2
Protein Name ORM1-like 2 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000243045
InnateDB Gene IDBG-39159 (ORMDL2)
Protein Structure
UniProt Annotation
Function Negative regulator of sphingolipid synthesis. {ECO:0000269PubMed:20182505}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:12093374}; Multi-pass membrane protein {ECO:0000269PubMed:12093374}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. {ECO:0000269PubMed:12093374}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006672 ceramide metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007203 ORMDL
PFAM PF04061
PRINTS
PIRSF PIRSF018147
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53FV1
PhosphoSite PhosphoSite-Q53FV1
TrEMBL F8VXD5
UniProt Splice Variant
Entrez Gene 29095
UniGene Hs.734057
RefSeq NP_054901
HUGO HGNC:16037
OMIM 610074
CCDS CCDS8893
HPRD 17802
IMGT
EMBL AB064961 AC023055 AF161509 AF173375 AF395705 AF395706 AF395707 AK223180 AK314046 BC012543 CH471054
GenPept AAF29124 AAH12543 AAM43504 AAM43505 AAM43506 AAQ13618 BAC11712 BAD96900 BAG36755 EAW96840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca