InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NQO1

Summary

InnateDB Protein

IDBP-39431.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NQO1

Protein Name

NAD(P)H dehydrogenase, quinone 1

Synonyms

DHQU; DIA4; DTD; NMOR1; NMORI; QR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000368335

InnateDB Gene

IDBG-39427 (NQO1)

Protein Structure

UniProt Annotation

Function

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003955	NAD(P)H dehydrogenase (quinone) activity
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006521	regulation of cellular amino acid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0007271	synaptic transmission, cholinergic
GO:0009636	response to toxic substance
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process