InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCKR

Summary

InnateDB Protein

IDBP-39960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCKR

Protein Name

glucokinase (hexokinase 4) regulator

Synonyms

FGQTL5; GKRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000264717

InnateDB Gene

IDBG-39958 (GCKR)

Protein Structure

UniProt Annotation

Function

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. {ECO:0000269PubMed:23621087, ECO:0000269PubMed:23733961}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10456334}. Nucleus {ECO:0000269PubMed:10456334}. Note=Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.

Disease Associations

Tissue Specificity

Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. {ECO:0000269PubMed:19643913, ECO:0000269PubMed:9570959}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030246	carbohydrate binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0008645	hexose transport
GO:0009750	response to fructose
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0033132	negative regulation of glucokinase activity
GO:0033133	positive regulation of glucokinase activity
GO:0043086	negative regulation of catalytic activity
GO:0044281	small molecule metabolic process
GO:0046415	urate metabolic process
GO:0055085	transmembrane transport
GO:0070328	triglyceride homeostasis