Version 5.4
Homo sapiens Protein: LDLRAD3
Summary
InnateDB Protein IDBP-39963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDLRAD3
Protein Name low density lipoprotein receptor class A domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000318607
InnateDB Gene IDBG-39961 (LDLRAD3)
Protein Structure
UniProt Annotation
Function May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver. {ECO:0000269PubMed:21795536}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0070613 regulation of protein processing
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
PFAM PF00057
PRINTS PR00261
PIRSF
SMART SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86YD5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 143458
UniGene Hs.741559
RefSeq NP_777562
HUGO HGNC:27046
OMIM
CCDS CCDS31462
HPRD 14063
IMGT
EMBL AC026269 AC087277 AC129502 AK075546 AL136146 BC042754 BC136286 CH471064
GenPept AAH42754 AAI36287 BAC11689 EAW68127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca