InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syt8

Summary

InnateDB Protein

IDBP-400120.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syt8

Protein Name

synaptotagmin VIII

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112689

InnateDB Gene

IDBG-212545 (Syt8)

Protein Structure

UniProt Annotation

Function

Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)- regulation of exocytosis in insulin secreted cells. {ECO:0000269PubMed:11751263, ECO:0000269PubMed:15774481, ECO:0000269PubMed:7791877}.

Subcellular Localization

Cytoplasm. Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in testis and brain. Expressed in primary neurons, neuroendocrine and endocrine cells. {ECO:0000269PubMed:11751263, ECO:0000269PubMed:16386321}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006810	transport
GO:0007340	acrosome reaction

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031988	membrane-bounded vesicle