InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Runx3

Summary

InnateDB Protein

IDBP-400128.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Runx3

Protein Name

runt related transcription factor 3

Synonyms

AML2; Cbfa3; Pebp2a3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113159

InnateDB Gene

IDBG-196773 (Runx3)

Protein Structure

UniProt Annotation

Function

Binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. May be involved in the control of cellular proliferation and/or differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Note=The tyrosine phosphorylated form localizes to the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	2 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002062	chondrocyte differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007411	axon guidance
GO:0031069	hair follicle morphogenesis
GO:0031175	neuron projection development
GO:0032609	interferon-gamma production
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045786	negative regulation of cell cycle
GO:0048469	cell maturation
GO:0050680	negative regulation of epithelial cell proliferation
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:102672

InterPro

IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
IPR008967 p53-like transcription factor, DNA-binding
IPR013524 Runt domain
IPR013711 Runx, C-terminal domain
IPR016554 Runt-related transcription factor RUNX

PFAM

PF00853
PF08504

PRINTS

PR00967

PIRSF

PIRSF009374

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt