InnateDB Protein
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IDBP-40017.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CYC1
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Protein Name
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cytochrome c-1
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Synonyms
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MC3DN6; UQCR4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000317159
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InnateDB Gene
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IDBG-40015 (CYC1)
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Protein Structure
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Function |
This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.
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Subcellular Localization |
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
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Disease Associations |
Mitochondrial complex III deficiency, nuclear 6 (MC3DN6) [MIM:615453]: An autosomal recessive disorder caused by mitochondrial dysfunction. It is characterized by onset in early childhood of episodic acute lactic acidosis, ketoacidosis, and insulin-responsive hyperglycemia, usually associated with infection. Laboratory studies show decreased activity of mitochondrial complex III. Psychomotor development is normal. {ECO:0000269PubMed:23910460}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
29
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005506
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iron ion binding
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GO:0009055
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electron carrier activity
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GO:0020037
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heme binding
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GO:0045155
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electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002326
Cytochrome c1
IPR009056
Cytochrome c-like domain
IPR021157
Cytochrome c1, transmembrane anchor, C-terminal
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PFAM |
PF02167
PF13442
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PRINTS |
PR00603
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P08574
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PhosphoSite |
PhosphoSite-P08574
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1537
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UniGene |
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RefSeq |
NP_001907
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HUGO |
HGNC:2579
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OMIM |
123980
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CCDS |
CCDS6415
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HPRD |
00480
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IMGT |
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EMBL |
AC104592
BC001006
BC015616
BC020566
BT019798
CR541674
DQ300360
J04444
M16597
X06994
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GenPept |
AAA35730
AAA52135
AAH01006
AAH15616
AAH20566
AAV38601
ABB96244
CAA30052
CAG46475
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