InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Orai1

Summary

InnateDB Protein

IDBP-400266.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Orai1

Protein Name

ORAI calcium release-activated calcium modulator 1

Synonyms

D730049H07Rik; orai-1; Tmem142a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113097

InnateDB Gene

IDBG-199057 (Orai1)

Protein Structure

UniProt Annotation

Function

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015279	store-operated calcium channel activity

Biological Process

GO:0002115	store-operated calcium entry
GO:0002376	immune system process
GO:0045087	innate immune response (InnateDB)
GO:0051924	regulation of calcium ion transport
GO:0051928	positive regulation of calcium ion transport
GO:0070588	calcium ion transmembrane transport