InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mbd6

Summary

InnateDB Protein

IDBP-400365.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbd6

Protein Name

methyl-CpG binding domain protein 6

Synonyms

D10Wsu93e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112805

InnateDB Gene

IDBG-194835 (Mbd6)

Protein Structure

UniProt Annotation

Function

Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin in about 25% of the cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at highest levels in adult testis and brain. {ECO:0000269PubMed:20700456}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

MGI:106378

InterPro

IPR001739 Methyl-CpG DNA binding
IPR016177 DNA-binding domain

PFAM

PF01429

PRINTS

PIRSF

SMART

SM00391

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3TY92

PhosphoSite

PhosphoSite-

TrEMBL

Q7TMJ0

UniProt Splice Variant

Entrez Gene

110962

UniGene

Mm.441266

RefSeq

XP_006513138

MGI ID

MGI Symbol

Mbd6

OMIM

CCDS

HPRD

IMGT

EMBL

AC144852 AK158797 BC055445 BC083328 CH466578

GenPept

AAH55445 AAH83328 BAE34671 EDL24491