Version 5.4
Mus musculus Protein: Fam20b
Summary
InnateDB Protein IDBP-400369.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam20b
Protein Name family with sequence similarity 20, member B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000112534
InnateDB Gene IDBG-200460 (Fam20b)
Protein Structure
UniProt Annotation
Function Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Little expression detected in the secretory stage enamel. Weak to moderate expression is observed in the gingivae and odontoblasts. Strong expression in maturation stage ameloblasts. {ECO:0000269PubMed:21549343}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0016310 phosphorylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2443990
InterPro IPR009581 Domain of unknown function DUF1193
PFAM PF06702
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VCS3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 215015
UniGene Mm.229107
RefSeq XP_006496799
MGI ID
MGI Symbol Fam20b
OMIM
CCDS CCDS15395
HPRD
IMGT
EMBL AK049705 AK129154 AK132149 BC019381 BC023737 BC024412 BC031473 CH466520
GenPept AAH19381 AAH23737 AAH24412 AAH31473 BAC33883 BAC97964 BAE20998 EDL39377

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca