InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdh13

Summary

InnateDB Protein

IDBP-400412.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh13

Protein Name

cadherin 13

Synonyms

4932416G01Rik; Cdht; T-cadherin; Tcad;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113527

InnateDB Gene

IDBG-195276 (Cdh13)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding
GO:0042803	protein homodimerization activity
GO:0045296	cadherin binding
GO:0055100	adiponectin binding
GO:0071813	lipoprotein particle binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0001558	regulation of cell growth
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0007156	homophilic cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007266	Rho protein signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0016339	calcium-dependent cell-cell adhesion
GO:0016601	Rac protein signal transduction
GO:0030032	lamellipodium assembly
GO:0030100	regulation of endocytosis
GO:0030335	positive regulation of cell migration
GO:0042058	regulation of epidermal growth factor receptor signaling pathway
GO:0043542	endothelial cell migration
GO:0043616	keratinocyte proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050927	positive regulation of positive chemotaxis
GO:0051668	localization within membrane
GO:0055096	low-density lipoprotein particle mediated signaling

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome