Version 5.4
Mus musculus Protein: Nrip2
Summary
InnateDB Protein IDBP-400462.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrip2
Protein Name nuclear receptor interacting protein 2
Synonyms AW491344; NIX1;
Species Mus musculus
Ensembl Protein ENSMUSP00000113317
InnateDB Gene IDBG-191101 (Nrip2)
Protein Structure
UniProt Annotation
Function Down-regulates transcriptional activation by nuclear receptors, such as NR1F2. {ECO:0000269PubMed:10860982}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10860982}.
Disease Associations
Tissue Specificity Expression is restricted to the central nervous system (neurons in the dentate gyrus of the hippocampus, the amygdala, thalamic and hypothalamic regions). {ECO:0000269PubMed:10860982}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1891884
InterPro IPR019103 Aspartic peptidase, DDI1-type
IPR021109 Aspartic peptidase domain
PFAM PF09668
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JHR9
PhosphoSite PhosphoSite-Q9JHR9
TrEMBL
UniProt Splice Variant
Entrez Gene 60345
UniGene Mm.269883
RefSeq NP_001156330
MGI ID
MGI Symbol Nrip2
OMIM
CCDS CCDS51917
HPRD
IMGT
EMBL AJ278170 AK134689 AK156526 BC115523
GenPept AAI15524 BAE22242 BAE33744 CAB95737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca