InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 2610002M06Rik

Summary

InnateDB Protein

IDBP-400564.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

2610002M06Rik

Protein Name

RIKEN cDNA 2610002M06 gene

Synonyms

2810405I11Rik; 8430408J07Rik; AI876413; Chmp1b1; Chmp1b2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113588

InnateDB Gene

IDBG-167744 (2610002M06Rik)

Protein Structure

UniProt Annotation

Function

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Endosome {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000910	cytokinesis
GO:0008150	biological_process
GO:0015031	protein transport
GO:0045184	establishment of protein localization

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1914278

InterPro

IPR005024 Snf7

PFAM

PF03357

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQD4

PhosphoSite

PhosphoSite-Q9CQD4

TrEMBL

UniProt Splice Variant

Entrez Gene

67064

UniGene

Mm.398099

RefSeq

NP_080197

MGI ID

MGI Symbol

2610002M06Rik

OMIM

CCDS

CCDS53171

HPRD

IMGT

EMBL

AK011297 AK019383 AL669851 AL844897 BC016070

GenPept

AAH16070 BAB27525 BAB31692 CAM16985 CAM19700