Mus musculus Protein: Megf11 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-400875.4 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Megf11 | ||||||
Protein Name | multiple EGF-like-domains 11 | ||||||
Synonyms | |||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000114035 | ||||||
InnateDB Gene | IDBG-176379 (Megf11) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. {ECO:0000269PubMed:22407321}. | ||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10 (By similarity). {ECO:0000250}. | ||||||
Disease Associations | |||||||
Tissue Specificity | |||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:1920951 | ||||||
InterPro |
IPR000742
Epidermal growth factor-like domain IPR002049 EGF-like, laminin IPR011489 EMI domain IPR013111 EGF-like domain, extracellular |
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PFAM |
PF00008
PF00053 PF07546 PF07974 |
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PRINTS | |||||||
PIRSF | |||||||
SMART |
SM00181
SM00180 |
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TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q80T91 | ||||||
PhosphoSite | PhosphoSite-Q80T91 | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 214058 | ||||||
UniGene | Mm.127721 | ||||||
RefSeq | XP_006511050 | ||||||
MGI ID | |||||||
MGI Symbol | Megf11 | ||||||
OMIM | |||||||
CCDS | |||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AK048840 AK051642 AK122555 AK160406 | ||||||
GenPept | BAC33471 BAC34702 BAC65837 BAE35774 | ||||||