InnateDB Protein
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IDBP-400889.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zwilch
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Protein Name
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Zwilch, kinetochore associated, homolog (Drosophila)
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Synonyms
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2310031L18Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112790
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InnateDB Gene
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IDBG-175909 (Zwilch)
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Protein Structure
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Function |
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (By similarity). {ECO:0000250}.
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Subcellular Localization |
Chromosome, centromere, kinetochore {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915264
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InterPro |
IPR018630
RZZ complex, subunit zwilch
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PFAM |
PF09817
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R060
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PhosphoSite |
PhosphoSite-Q8R060
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TrEMBL |
H3BKZ0
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UniProt Splice Variant |
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Entrez Gene |
68014
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UniGene |
Mm.474670
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RefSeq |
NP_080783
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MGI ID |
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MGI Symbol |
Zwilch
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OMIM |
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CCDS |
CCDS23275
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HPRD |
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IMGT |
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EMBL |
AC114674
AC160118
AK009559
AK019825
BC027435
CH466522
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GenPept |
AAH27435
BAB26358
BAB31869
EDL26055
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