InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lias

Summary

InnateDB Protein

IDBP-400935.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lias

Protein Name

lipoic acid synthetase

Synonyms

2900022L22Rik; 4933425M12Rik; 7a5ex; C77512; mLip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113228

InnateDB Gene

IDBG-166563 (Lias)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016992	lipoate synthase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0001843	neural tube closure
GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0009107	lipoate biosynthetic process
GO:0009249	protein lipoylation
GO:0032496	response to lipopolysaccharide

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1934604

InterPro

IPR003698 Lipoyl synthase
IPR006638 Elongator protein 3/MiaB/NifB
IPR007197 Radical SAM

PFAM

PF04055

PRINTS

PIRSF

PIRSF005963

SMART

SM00729

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z6I3

UniProt Splice Variant

Entrez Gene

79464

UniGene

Mm.348664

RefSeq

MGI ID

MGI Symbol

Lias

OMIM

CCDS

HPRD

IMGT

EMBL

AC136513

GenPept