InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Celf6

Summary

InnateDB Protein

IDBP-400951.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Celf6

Protein Name

CUGBP, Elav-like family member 6

Synonyms

6330569O16Rik; Brunol6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113196

InnateDB Gene

IDBG-172924 (Celf6)

Protein Structure

UniProt Annotation

Function

RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

Biological Process

GO:0006397

mRNA processing

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1923433

InterPro

IPR000504 RNA recognition motif domain

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TN33

PhosphoSite

PhosphoSite-Q7TN33

TrEMBL

UniProt Splice Variant

Entrez Gene

76183

UniGene

Mm.265415

RefSeq

XP_006511609

MGI ID

MGI Symbol

Celf6

OMIM

CCDS

HPRD

IMGT

EMBL

AK034216 BC052406 BC057083

GenPept

AAH52406 AAH57083 BAC28635