InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmp11

Summary

InnateDB Protein

IDBP-401062.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp11

Protein Name

matrix metallopeptidase 11

Synonyms

ST3; Stmy3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112940

InnateDB Gene

IDBG-164112 (Mmp11)

Protein Structure

UniProt Annotation

Function

May play an important role in the progression of epithelial malignancies.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305}.

Disease Associations

Tissue Specificity

Specifically expressed in the mammary gland during apoptosis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007275	multicellular organismal development
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process
GO:0045599	negative regulation of fat cell differentiation
GO:0071711	basement membrane organization

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:97008

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References