InnateDB Protein
|
IDBP-401126.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Bco2
|
Protein Name
|
beta-carotene oxygenase 2
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000112727
|
InnateDB Gene
|
IDBG-163405 (Bco2)
|
Protein Structure
|
|
Function |
Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. {ECO:0000269PubMed:21106934}.
|
Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:21106934}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
0
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0016702
|
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
GO:0046872
|
metal ion binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2177469
|
InterPro |
IPR004294
Carotenoid oxygenase
|
PFAM |
PF03055
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q99NF1
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
Q3KNZ2
|
UniProt Splice Variant |
|
Entrez Gene |
170752
|
UniGene |
Mm.390149
|
RefSeq |
NP_573480
|
MGI ID |
|
MGI Symbol |
Bco2
|
OMIM |
|
CCDS |
CCDS40620
|
HPRD |
|
IMGT |
|
EMBL |
AJ290392
BC107006
BC107007
CH466522
|
GenPept |
AAI07007
AAI07008
CAC28026
EDL25739
|
|
|