Version 5.4
Mus musculus Protein: Rdh12
Summary
InnateDB Protein IDBP-401423.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rdh12
Protein Name retinol dehydrogenase 12
Synonyms A930033N07Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000112543
InnateDB Gene IDBG-152851 (Rdh12)
Protein Structure
UniProt Annotation
Function Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050662 coenzyme binding
Biological Process
GO:0007601 visual perception
GO:0008152 metabolic process
GO:0042572 retinol metabolic process
GO:0044237 cellular metabolic process
GO:0050896 response to stimulus
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID MGI:1925224
InterPro IPR001509 NAD-dependent epimerase/dehydratase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF01370
PF00106
PF08659
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BYK4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 77974
UniGene Mm.474941
RefSeq
MGI ID
MGI Symbol Rdh12
OMIM
CCDS
HPRD
IMGT
EMBL AK020927 AK039233 BC016204
GenPept AAH16204 BAB32258 BAC30288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca