Version 5.4
Mus musculus Protein: Best1
Summary
InnateDB Protein IDBP-401503.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Best1
Protein Name bestrophin 1
Synonyms Bmd; mBest1; Vmd2;
Species Mus musculus
Ensembl Protein ENSMUSP00000113053
InnateDB Gene IDBG-142897 (Best1)
Protein Structure
UniProt Annotation
Function Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0030321 transepithelial chloride transport
GO:0050908 detection of light stimulus involved in visual perception
GO:0051924 regulation of calcium ion transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016323 basolateral plasma membrane
GO:0034707 chloride channel complex
Protein Structure and Domains
PDB ID MGI:1346332
InterPro IPR021134 Bestrophin/UPF0187
PFAM PF01062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88870
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 24115
UniGene Mm.31577
RefSeq NP_036043
MGI ID
MGI Symbol Best1
OMIM
CCDS CCDS29568
HPRD
IMGT
EMBL AF057171 AY450427 BC139060 BC139061
GenPept AAC64345 AAI39061 AAI39062 AAS09922

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca