Mus musculus Protein: Ppp2r2b
Summary
InnateDB Protein IDBP-401537.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp2r2b
Protein Name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
Synonyms 2900026H06Rik; 6330404L05Rik; E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12;
Species Mus musculus
Ensembl Protein ENSMUSP00000113411
InnateDB Gene IDBG-143462 (Ppp2r2b)
Protein Structure
UniProt Annotation
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance. {ECO:0000250}.
Subcellular Localization Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Membrane.Isoform 2: Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, testis, lung and spleen. In the brain, expressed in the cortex, hippocampus and cerebellum (at protein level). {ECO:0000269PubMed:12473071}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:1920180
InterPro IPR000009 Protein phosphatase 2A, regulatory subunit PR55
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS PR00600
PIRSF PIRSF037309
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZWR4
PhosphoSite PhosphoSite-Q6ZWR4
TrEMBL
UniProt Splice Variant
Entrez Gene 72930
UniGene Mm.408724
RefSeq XP_006526348
MGI ID
MGI Symbol Ppp2r2b
OMIM
CCDS
HPRD
IMGT
EMBL AF512670 AF536771 AK013600 AK018119 AK039592 AK148956 BC026686 BC088979 CH466528
GenPept AAH26686 AAH88979 AAM46987 AAN05641 BAB28921 BAB31079 BAC30395 BAE28701 EDL10024 EDL10025