Mus musculus Protein: Lrfn5 | |||||
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Summary | |||||
InnateDB Protein | IDBP-401589.4 | ||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
Gene Symbol | Lrfn5 | ||||
Protein Name | leucine rich repeat and fibronectin type III domain containing 5 | ||||
Synonyms | |||||
Species | Mus musculus | ||||
Ensembl Protein | ENSMUSP00000113123 | ||||
InnateDB Gene | IDBG-142638 (Lrfn5) | ||||
Protein Structure | |||||
UniProt Annotation | |||||
Function | Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity). {ECO:0000250}. | ||||
Subcellular Localization | Membrane {ECO:0000269PubMed:16828986}; Single-pass type I membrane protein {ECO:0000269PubMed:16828986}. | ||||
Disease Associations | |||||
Tissue Specificity | Predominantly expressed in the brain, with a weak, but broad expression in the cerebral cortex and diencephalic nuclei. Strongly expressed in both the pyramidal layer and the dentate gyrus of the hippocampus. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. {ECO:0000269PubMed:16828986}. | ||||
Comments | |||||
Interactions | |||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||
PDB ID | MGI:2144814 | ||||
InterPro |
IPR001611
Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype IPR003598 Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR003961 Fibronectin, type III IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013151 Immunoglobulin |
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PFAM |
PF00560
PF13504 PF13855 PF00041 PF01108 PF07679 PF00047 |
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PRINTS | |||||
PIRSF | |||||
SMART |
SM00369
SM00408 SM00409 SM00060 |
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TIGRFAMs | |||||
Post-translational Modifications | |||||
Modification | |||||
Cross-References | |||||
SwissProt | Q8BXA0 | ||||
PhosphoSite | PhosphoSite-Q8BXA0 | ||||
TrEMBL | |||||
UniProt Splice Variant | |||||
Entrez Gene | 238205 | ||||
UniGene | Mm.486895 | ||||
RefSeq | XP_006515895 | ||||
MGI ID | |||||
MGI Symbol | Lrfn5 | ||||
OMIM | |||||
CCDS | |||||
HPRD | |||||
IMGT | |||||
EMBL | AK034245 AK048443 AK220546 BC052038 | ||||
GenPept | AAH52038 BAC28645 BAC33339 BAD90535 | ||||