Version 5.4
Mus musculus Protein: Kcnmb2
Summary
InnateDB Protein IDBP-401606.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnmb2
Protein Name potassium large conductance calcium-activated channel, subfamily M, beta member 2
Synonyms 2700049B16Rik; 3110031N04Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000113234
InnateDB Gene IDBG-136457 (Kcnmb2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015269 calcium-activated potassium channel activity
Biological Process
GO:0005513 detection of calcium ion
GO:0006813 potassium ion transport
GO:0019228 neuronal action potential
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1919663
InterPro IPR003930 Potassium channel, calcium-activated, BK, beta subunit
IPR015382 KCNMB2, ball/chain domain
PFAM PF03185
PF09303
PRINTS PR01450
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CZM9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 72413
UniGene Mm.64790
RefSeq NP_082507
MGI ID
MGI Symbol Kcnmb2
OMIM
CCDS CCDS17292
HPRD
IMGT
EMBL AK012400 AY062429 BC046227 BC058957
GenPept AAH46227 AAH58957 AAL38982 BAB28216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca