Version 5.4
Mus musculus Protein: Tspan12
Summary
InnateDB Protein IDBP-401641.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tspan12
Protein Name tetraspanin 12
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113384
InnateDB Gene IDBG-129430 (Tspan12)
Protein Structure
UniProt Annotation
Function Regulator of cell surface receptor signal transduction. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta- catenin (CTNNB1). {ECO:0000250, ECO:0000269PubMed:19837033}.
Subcellular Localization Cell membrane {ECO:0000305PubMed:19837033}; Multi-pass membrane protein {ECO:0000305PubMed:19837033}.
Disease Associations
Tissue Specificity Expressed in the neonatal retinal vasculature but not other retinal tissues. Also detected in the neonatal meningeal vasculature and in nonvascular cell types, such as the smooth muscle cells in the neonatal intestine. {ECO:0000269PubMed:19837033}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0007166 cell surface receptor signaling pathway
GO:0010842 retina layer formation
GO:0045765 regulation of angiogenesis
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1889818
InterPro IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BKT6
PhosphoSite PhosphoSite-
TrEMBL D3YYV7
UniProt Splice Variant
Entrez Gene 269831
UniGene Mm.401178
RefSeq
MGI ID
MGI Symbol Tspan12
OMIM
CCDS
HPRD
IMGT
EMBL AC122421 AC163104 AK033554 AK050737 BC065152 BC068240 CH466533
GenPept AAH65152 AAH68240 BAC28354 BAC34399 EDL13857

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca