InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO1D

Summary

InnateDB Protein

IDBP-40258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO1D

Protein Name

myosin ID

Synonyms

myr4; PPP1R108;

Species

Homo sapiens

Ensembl Protein

ENSP00000324527

InnateDB Gene

IDBG-40256 (MYO1D)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0010923	negative regulation of phosphatase activity
GO:0061502	early endosome to recycling endosome transport

Cellular Component

GO:0005768	endosome
GO:0005790	smooth endoplasmic reticulum
GO:0016459	myosin complex
GO:0030673	axolemma
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR010926 Myosin tail 2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF06017

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt