InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHSY3

Summary

InnateDB Protein

IDBP-40300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHSY3

Protein Name

chondroitin sulfate synthase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000302629

InnateDB Gene

IDBG-40298 (CHSY3)

Protein Structure

UniProt Annotation

Function

Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. {ECO:0000269PubMed:12907687}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000305PubMed:12907687}; Single-pass type II membrane protein {ECO:0000305PubMed:12907687}.

Disease Associations

Tissue Specificity

Detected at low levels in brain, cerebral cortex, uterus and small intestine. {ECO:0000269PubMed:12907687}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008376	acetylgalactosaminyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0046872	metal ion binding
GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process