InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSD17B12

Summary

InnateDB Protein

IDBP-40503.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD17B12

Protein Name

hydroxysteroid (17-beta) dehydrogenase 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000278353

InnateDB Gene

IDBG-40501 (HSD17B12)

Protein Structure

UniProt Annotation

Function

Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation. {ECO:0000269PubMed:12482854, ECO:0000269PubMed:16166196}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12482854}; Multi-pass membrane protein {ECO:0000269PubMed:12482854}.

Disease Associations

Tissue Specificity

Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets. {ECO:0000269PubMed:12482854, ECO:0000269PubMed:16113833, ECO:0000269PubMed:16166196}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008201	heparin binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0008152	metabolic process
GO:0010811	positive regulation of cell-substrate adhesion
GO:0019432	triglyceride biosynthetic process
GO:0030198	extracellular matrix organization
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process