InnateDB Protein
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IDBP-40557.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ALKBH3
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Protein Name
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alkB, alkylation repair homolog 3 (E. coli)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302232
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InnateDB Gene
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IDBG-40555 (ALKBH3)
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Protein Structure
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Function |
Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269PubMed:12486230, ECO:0000269PubMed:12594517, ECO:0000269PubMed:16174769, ECO:0000269PubMed:22055184}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon. {ECO:0000269PubMed:12486230, ECO:0000269PubMed:16174769, ECO:0000269PubMed:17979886}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0008198
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ferrous iron binding
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GO:0016491
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oxidoreductase activity
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GO:0016706
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
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GO:0031418
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L-ascorbic acid binding
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GO:0043734
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DNA-N1-methyladenine dioxygenase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005123
Oxoglutarate/iron-dependent dioxygenase
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PFAM |
PF03171
PF13640
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96Q83
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PhosphoSite |
PhosphoSite-Q96Q83
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TrEMBL |
E9PRD0
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UniProt Splice Variant |
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Entrez Gene |
221120
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UniGene |
Hs.720708
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RefSeq |
NP_631917
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HUGO |
HGNC:30141
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OMIM |
610603
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CCDS |
CCDS7906
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HPRD |
16793
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IMGT |
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EMBL |
AB042029
AC087521
BC015155
BC067257
BC103812
BC103813
BC103814
CH471064
DQ196343
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GenPept |
AAH15155
AAH67257
AAI03813
AAI03814
AAI03815
ABA27096
BAB70508
EAW68078
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