Homo sapiens Protein: SMO
InnateDB Protein IDBP-40671.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMO
Protein Name smoothened, frizzled family receptor
Synonyms FZD11; Gx; SMOH;
Species Homo sapiens
Ensembl Protein ENSP00000249373
InnateDB Gene IDBG-40669 (SMO)
Protein Structure
UniProt Annotation
Function G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. {ECO:0000269PubMed:19592253}.
Subcellular Localization Membrane {ECO:0000269PubMed:22072986}; Multi-pass membrane protein {ECO:0000269PubMed:22072986}. Cell projection, cilium {ECO:0000269PubMed:22072986}.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005113 patched binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001503 ossification
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001755 neural crest cell migration
GO:0001947 heart looping
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003007 heart morphogenesis
GO:0003140 determination of left/right asymmetry in lateral mesoderm
GO:0003323 type B pancreatic cell development
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007228 positive regulation of hh target transcription factor activity
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007371 ventral midline determination
GO:0007389 pattern specification process
GO:0007417 central nervous system development
GO:0007494 midgut development
GO:0008284 positive regulation of cell proliferation
GO:0008406 gonad development
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010002 cardioblast differentiation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0021508 floor plate formation
GO:0021561 facial nerve development
GO:0021696 cerebellar cortex morphogenesis
GO:0021794 thalamus development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953 central nervous system neuron differentiation
GO:0021984 adenohypophysis development
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031017 exocrine pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0031102 neuron projection regeneration
GO:0032474 otolith morphogenesis
GO:0034504 protein localization to nucleus
GO:0035264 multicellular organism growth
GO:0042307 positive regulation of protein import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042693 muscle cell fate commitment
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048589 developmental growth
GO:0048663 neuron fate commitment
GO:0048702 embryonic neurocranium morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0048741 skeletal muscle fiber development
GO:0048752 semicircular canal morphogenesis
GO:0048846 axon extension involved in axon guidance
GO:0048853 forebrain morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050821 protein stabilization
GO:0051451 myoblast migration
GO:0051799 negative regulation of hair follicle development
GO:0060070 canonical Wnt signaling pathway
GO:0060248 detection of cell density by contact stimulus involved in contact inhibition
GO:0060413 atrial septum morphogenesis
GO:0060644 mammary gland epithelial cell differentiation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway
GO:0061053 somite development
GO:0061113 pancreas morphogenesis
GO:0071397 cellular response to cholesterol
GO:0072001 renal system development
GO:0072285 mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:2000036 regulation of stem cell maintenance
GO:2000826 regulation of heart morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005929 cilium
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
GO:0060170 ciliary membrane
GO:0070062 extracellular vesicular exosome
GO:0072372 primary cilium
Protein Structure and Domains
InterPro IPR000539 Frizzled protein
IPR000832 GPCR, family 2, secretin-like
IPR017981 GPCR, family 2-like
IPR020067 Frizzled domain
PFAM PF01534
Post-translational Modifications
SwissProt Q99835
PhosphoSite PhosphoSite-Q99835
UniProt Splice Variant
Entrez Gene 6608
UniGene Hs.630582
RefSeq NP_005622
OMIM 601500
HPRD 03294
EMBL AF071494 AF114819 AF114820 AF114821 AF120103 BC009989 CH236950 CH471070 U84401
GenPept AAB41788 AAC24863 AAD17202 AAF31757 AAH09989 EAL24102 EAW83715