InnateDB Protein
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IDBP-40755.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ERC2
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Protein Name
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ELKS/RAB6-interacting/CAST family member 2
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Synonyms
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CAST; CAST1; ELKSL; SPBC110; Spc110;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000288221
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InnateDB Gene
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IDBG-40751 (ERC2)
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Protein Structure
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Function |
Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12923177}. Cell junction, synapse {ECO:0000269PubMed:12923177}. Cell junction, synapse, synaptosome {ECO:0000269PubMed:12923177}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12923177}. Note=In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009053
Prefoldin
IPR019323
CAZ complex, RIM-binding protein
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PFAM |
PF10174
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O15083
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PhosphoSite |
PhosphoSite-O15083
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26059
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UniGene |
Hs.693223
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RefSeq |
NP_056391
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HUGO |
HGNC:31922
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OMIM |
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CCDS |
CCDS46851
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HPRD |
10810
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IMGT |
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EMBL |
AB002376
BC046212
BC111550
BC112391
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GenPept |
AAI11551
AAI12392
BAA20832
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