InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF431

Summary

InnateDB Protein

IDBP-40777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF431

Protein Name

zinc finger protein 431

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000308578

InnateDB Gene

IDBG-40775 (ZNF431)

Protein Structure

UniProt Annotation

Function

Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0003676	nucleic acid binding
GO:0003682	chromatin binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030154	cell differentiation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity